Publications

Serena Tamura, Andrew D Nelson, Perry WE Spratt, Elizabeth C Hamada, Xujia Zhou, Henry Kyoung, Zizheng Li, Coline Arnould, Vladyslav Barskyi, Beniamin Krupkin, Kiana Young, Jingjing Zhao, Stephanie S Holden, Atehsa Sahagun, Caroline M Keeshen, Congyi Lu, Roy Ben-Shalom, Sunrae E Taloma, Selin Schamiloglu, Ying C Li, Lia Min, Paul M Jenkins, Jen Q Pan, Jeanne T Paz, Stephan J Sanders, Navneet Matharu, Nadav Ahituv, Kevin J Bender. CRISPR activation for SCN2A-related neurodevelopmental disorders. Nature (2025). https://doi.org/10.1038/s41586-025-09522-w

Garcia JD, Wang C, Alexander RP, Banks E, Fenton T, DeKeyser JM, Abramova TV, George Jr AL, Ben-Shalom R, Hackos DH, Bender KJ. Differential roles of NaV1. 2 and NaV1. 6 in neocortical pyramidal cell excitability. Elife. 2025 Jul 15;14:RP105696 https://doi.org/10.7554/eLife.105696.3.

Haghani, V., Ali, S. M., Cannizzaro, N., Patil, M. M., Sullivan, P. D., Rehamn, A., Green, R., Ben-Shalom, R., LaSalle, J. M., & Zarbalis, K. (2025). Excess prenatal folic acid supplementation alters cortical gene expression networks and electrophysiology. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2025.05.07.652681

Fink, K., Halmai, J., Cameron, D., Gonzalez, C., Singh, M., Ansari, A., Haghani, V., Monsen, E., Paynton-Cheney, A., Waldo, J., Fenton, T., Ben-Shalom, R., & Silverman, J. (2025). Epigenetic reactivation of CDKL5 rescues CDKL5 deficiency Disorder. Research Square (Research Square). https://doi.org/10.21203/rs.3.rs-7095603/v1

Olguin, S. L., Davis, D., Rehman, A., Sahagun, E., Oswalt, P. S., Patil, M., Sullivan, P. D., Zhang, B., Bryda, E. C., Ben-Shalom, R., & Silverman, J. L. (2025). Novel gain of function mouse model of KCNT1-Related Epilepsy. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2025.07.22.666003

Clatot, J., Thompson, C. H., Sotardi, S., Jiang, J., Trivisano, M., Balestrini, S., Ward, D. I., Ginn, N., Guaragni, B., Malerba, L., Vakrinou, A., Sherer, M., Helbig, I., Somarowthu, A., Sisodiya, S. M., Ben‐Shalom, R., Guerrini, R., Specchio, N., George, A. L., & Goldberg, E. M. (2024). Rare dysfunctional SCN2A variants are associated with malformation of cortical development. Epilepsia. https://doi.org/10.1111/epi.18234

Quinn, S., Zhang, N., Fenton, T. A., Brusel, M., Muruganandam, P., Peleg, Y., Giladi, M., Haitin, Y., Lerche, H., Bassan, H., Liu, Y., Ben-Shalom, R., & Rubinstein, M. (2024). Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy. Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease, 1870(5), 167127. https://doi.org/10.1016/j.bbadis.2024.167127

Fenton T. A., Haouchine, O. Y., Hallam, E. B., Smith, E. M., Jackson, K. C., Rahbarian, D., Canales, C. P., Adhikari, A., Nord, A. S., Ben-Shalom, R., & Silverman, J. L. (2024). Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability. Translational Psychiatry, 14(1). https://doi.org/10.1038/s41398-024-03077-6

Ben-Shalom, Roy, Alexander Ladd, Nikhil S. Artherya, Christopher Cross, Kyung Geun Kim, Hersh Sanghevi, Alon Korngreen, Kristofer E. Bouchard, and Kevin J. Bender. "NeuroGPU: Accelerating multi-compartment, biophysically detailed neuron simulations on GPUs." Journal of neuroscience methods 366 (2022): 109400. https://doi.org/10.1016/j.jneumeth.2021.109400

Dennis M Echevarria-Cooper, Nicole A Hawkins, Sunita N Misra, Alexandra M Huffman, Tyler Thaxton, Christopher H Thompson, Roy Ben-Shalom, Andrew D Nelson, Anna M Lipkin, Alfred L George Jr, Kevin J Bender, Jennifer A Kearney, Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422E mice, Human Molecular Genetics, Volume 31, Issue 17, 1 September 2022, Pages 2964–2988. https://doi.org/10.1093/hmg/ddac087

Ladd A, Kim KG, Balewski J, Bouchard K and Ben-Shalom R (2022) Scaling and Benchmarking an Evolutionary Algorithm for Constructing Biophysical Neuronal Models. Front. Neuroinform. 16:882552. https://doi.org/10.3389/fninf.2022.882552

Spratt, Perry WE, Ryan PD Alexander, Roy Ben-Shalom, Atehsa Sahagun, Henry Kyoung, Caroline M. Keeshen, Stephan J. Sanders, and Kevin J. Bender. "Paradoxical hyperexcitability from NaV1. 2 sodium channel loss in neocortical pyramidal cells." Cell reports 36, no. 5 (2021). https://doi.org/10.1016/j.celrep.2021.109483

Thompson, C. H., Ben-Shalom, R., Bender, K. J., & George, A. L. (2020). Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants. The Journal of General Physiology, 152(3). https://doi.org/10.1085/jgp.201912442

Spratt, Perry WE, Roy Ben-Shalom, Caroline M. Keeshen, Kenneth J. Burke, Rebecca L. Clarkson, Stephan J. Sanders, and Kevin J. Bender. "The autism-associated gene Scn2a contributes to dendritic excitability and synaptic function in the prefrontal cortex." Neuron 103, no. 4 (2019): 673-685. https://doi.org/10.1016/j.neuron.2019.05.037

Ben-Shalom, Roy, Caroline M. Keeshen, Kiara N. Berrios, Joon Y. An, Stephan J. Sanders, and Kevin J. Bender. "Opposing effects on NaV1. 2 function underlie differences between SCN2A variants observed in individuals with autism spectrum disorder or infantile seizures." Biological psychiatry 82, no. 3 (2017): 224-232. https://doi.org/10.1016/j.biopsych.2017.01.009

Ben-Shalom R, Liberman G and Korngreen A (2013) Accelerating compartmental modeling on a graphical processing unit. Front. Neuro inform. 7:4. https://doi.org/10.3389/fninf.2013.00004

Ben-Shalom, Roy, Amit Aviv, Benjamin Razon, and Alon Korngreen. "Optimizing ion channel models using a parallel genetic algorithm on graphical processors." Journal of Neuroscience Methods 206, no. 2 (2012): 183-194. https://doi.org/10.1016/j.jneumeth.2012.02.024